{"id":1024,"date":"2023-08-04T11:06:07","date_gmt":"2023-08-04T04:06:07","guid":{"rendered":"https:\/\/biomedmart.com.vn\/?p=1024"},"modified":"2023-08-04T11:06:07","modified_gmt":"2023-08-04T04:06:07","slug":"lieu-phap-te-bao-mien-dich-dang-mang-lai-hi-vong-moi-cho-benh-nhan-ung-thu","status":"publish","type":"post","link":"https:\/\/biomedmart.com.vn\/etc\/2023\/08\/04\/lieu-phap-te-bao-mien-dich-dang-mang-lai-hi-vong-moi-cho-benh-nhan-ung-thu\/","title":{"rendered":"Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111ang mang l\u1ea1i hi v\u1ecdng m\u1edbi cho b\u1ec7nh nh\u00e2n ung th\u01b0"},"content":{"rendered":"\n<p>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch l\u00e0 m\u1ed9t d\u1ea1ng \u0111i\u1ec1u tr\u1ecb m\u00e0 s\u1eed d\u1ee5ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u0111\u1ec3 t\u1ea5n c\u00f4ng lo\u1ea1i b\u1ecf t\u1ebf b\u00e0o ung th\u01b0. C\u00e1c chi\u1ebfn l\u01b0\u1ee3c n\u00e0y li\u00ean quan \u0111\u1ebfn vi\u1ec7c thu nh\u1eadn m\u00e1u ngo\u1ea1i vi \u0111\u1ec3 t\u00e1ch l\u1ea5y t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 sau \u0111\u00f3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh t\u0103ng sinh ch\u00fang trong ph\u00f2ng th\u00ed nghi\u1ec7m, hay c\u00f3 th\u1ec3 bi\u1ebfn \u0111\u1ed5i ch\u00fang \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0 tr\u01b0\u1edbc khi t\u0103ng sinh. \u0110i\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh l\u00e0 v\u00ec v\u1ed1n d\u0129 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 \u0111\u1eb7c t\u00ednh nh\u1eadn di\u1ec7n v\u00e0 lo\u1ea1i b\u1ecf c\u00e1c t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng, b\u1ecb nhi\u1ec5m virut\u2026 m\u00e0 c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh t\u1ebf b\u00e0o ung th\u01b0. Trong s\u1ed1 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 th\u1ef1c hi\u1ec7n ch\u1ee9c n\u0103ng n\u00e0y, t\u1ebf b\u00e0o lympho T v\u00e0 t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean NK l\u00e0 2 t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c quan t\u00e2m nhi\u1ec1u nh\u1ea5t.<\/p>\n\n\n\n<figure class=\"wp-block-video\"><video height=\"1080\" style=\"aspect-ratio: 1920 \/ 1080;\" width=\"1920\" controls src=\"https:\/\/biomedmart.com.vn\/etc\/wp-content\/uploads\/2023\/08\/Presentation1.mp4\"><\/video><\/figure>\n\n\n\n<p>C\u00e1c t\u1ebf b\u00e0o lympho T l\u00e0 nh\u1eefng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch m\u1ea1nh m\u1ebd, ch\u00fang c\u00f3 th\u1ec3 nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 th\u00f4ng qua vi\u1ec7c nh\u1eadn di\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0. Tuy nhi\u00ean, kh\u00f4ng ph\u1ea3i \u1edf t\u1ea5t c\u1ea3 b\u1ec7nh nh\u1eadn, c\u00e1c t\u1ebf b\u00e0o T \u0111\u1ec1u c\u00f3 th\u1ec3 nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0. Do \u0111\u00f3, trong th\u1eddi gian g\u1ea7n \u0111\u00e2y, nhi\u1ec1u c\u00e1ch ti\u1ebfp c\u1eadn \u0111\u00e3 theo h\u01b0\u1edbng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o T bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0 th\u00f4ng qua vi\u1ec7c g\u1eafn th\u00eam receptor tr\u00ean b\u1ec1 m\u1eb7t (g\u1ecdi kh\u1ea3m receptor hay receptor kh\u00e1ng nguy\u00ean kh\u1ea3m &#8211; CAR). \u1ede c\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y, c\u00e1c t\u1ebf b\u00e0o T s\u1ebd \u0111\u01b0\u1ee3c thu nh\u1eadn t\u1eeb b\u1ec7nh nh\u00e2n, sau \u0111\u00f3 \u0111\u01b0\u1ee3c chuy\u1ec3n gen v\u00e0 bi\u1ec3u hi\u1ec7n gen cho receptor l\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o. Vi\u1ec7c l\u00e0m n\u00e0y gi\u00fap t\u1ebf b\u00e0o T d\u1ec5 d\u00e0ng nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o ung th\u01b0. B\u1eb1ng c\u00e1ch n\u00e0y h\u00e0ng lo\u1ea1t c\u00e1c quy tr\u00ecnh k\u0129 thu\u1eadt \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p \u1edf M\u0129 v\u00e0 m\u1ed9t s\u1ed1 qu\u1ed1c gia kh\u00e1c nh\u01b0 b\u00ean d\u01b0\u1edbi:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Axicabtagene ciloleucel (Yescarta\u00ae):<\/strong> kh\u1ea3m CD19, \u0111i\u1ec1u tr\u1ecb lymphoma<\/li>\n\n\n\n<li><strong>Brexucabtagene autoleucel (Tecartus\u2122):<\/strong> kh\u1ea3m CD19, \u0111i\u1ec1u tr\u1ecb lymphoma v\u00e0 leukemia<\/li>\n\n\n\n<li><strong>Ciltacabtagene autoleucel (Carvykti\u2122): <\/strong>kh\u1ea3m BCMA \u0111i\u1ec1u tr\u1ecb myeloma<\/li>\n\n\n\n<li><strong>Idecabtagene vicleucel (Abecma\u2122): <\/strong>kh\u1ea3m BCMA \u0111i\u1ec1u tr\u1ecb myeloma<\/li>\n\n\n\n<li><strong>Lisocabtagene maraleucel (Breyanzi\u00ae): <\/strong>kh\u1ea3m CD19 \u0111i\u1ec1u tr\u1ecb lymphoma<\/li>\n\n\n\n<li><strong>Tisagenlecleucel (Kyrmriah\u00ae):<\/strong> kh\u1ea3m CD19, \u0111i\u1ec1u tr\u1ecb lymphoma v\u00e0 leukemia<\/li>\n<\/ul>\n\n\n\n<p>Tuy nhi\u00ean, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng CAR-T c\u00f2n nhi\u1ec1u h\u1ea1n ch\u1ebf nh\u01b0 chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cao (t\u1eeb 7 t\u1ec9 \u0111\u1ed3ng \u0111\u1ebfn 25 t\u1ec9 \u0111\u1ed3ng cho m\u1ed9t li\u1ec7u tr\u00ecnh (t\u1ea1i M\u0129)) v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a \u0111i\u1ec1u tr\u1ecb l\u1edbn. Do \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc v\u1eabn ph\u1ea3i t\u00ecm ki\u1ebfm c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o kh\u1ea3 thi h\u01a1n trong \u0111i\u1ec1u tr\u1ecb v\u00e0 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n\n\n\n<p>Trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi c\u00f3 m\u1ed9t s\u1ed1 lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c v\u1eabn c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 m\u1ea1nh m\u1ebd nh\u01b0ng t\u1ed3n t\u1ea1i l\u01b0\u1ee3ng r\u1ea5t th\u1ea5p (m\u1ed9t s\u1ed1 l\u00e0 r\u1ea5t hi\u1ebfm) l\u00e0 t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean NK, t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean c\u00f3 \u0111\u1eb7c t\u00ednh t\u1ebf b\u00e0o T (NKT) v\u00e0 t\u1ebf b\u00e0o T gamma delta. Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y n\u1ebfu \u0111\u01b0\u1ee3c ph\u00e2n t\u00e1ch v\u00e0 t\u0103ng sinh l\u01b0\u1ee3ng l\u1edbn th\u00e0nh c\u00f4ng, ch\u00fang s\u1ebd tr\u1edf th\u00e0nh c\u00f4ng c\u1ee5 h\u1eefu hi\u1ec7u trong vi\u1ec7c ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. \u0110\u00e3 c\u00f3 h\u00e0ng ngh\u00ecn nghi\u00ean c\u1ee9u \u0111\u00e3 xu\u1ea5t b\u1ea3n v\u1ec1 vi\u1ec7c nghi\u00ean c\u1ee9u c\u00e1c t\u1ebf b\u00e0o n\u00e0y t\u1eeb c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb, \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb in vitro, tr\u00ean \u0111\u1ed9ng v\u1eadt v\u00e0 tr\u00ean ng\u01b0\u1eddi t\u1eeb kh\u1eafp n\u01a1i tr\u00ean th\u1ebf gi\u1edbi.<\/p>\n\n\n\n<p>M\u1eb7c d\u00f9 tri\u1ec3n v\u1ecdng l\u1edbn, c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch NK, NKT\/CIK, Gamma delta T v\u1eabn g\u1eb7p nh\u1eefng th\u00e1ch th\u1ee9c l\u1edbn tr\u01b0\u1edbc khi th\u1ef1c s\u1ef1 tr\u1edf th\u00e0nh li\u1ec7u ph\u00e1p \u0111\u01b0\u1ee3c ch\u1ecdn l\u1ef1a \u0111\u1ec3 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ung th\u01b0 bao g\u1ed3m: (1) chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cao, (2) hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u00edt \u1ed5n \u0111\u1ecbnh.<\/p>\n\n\n\n<p>\u0110\u1ec3 gi\u1ea3i quy\u1ebft nh\u1eefng th\u00e1ch th\u1ee9c l\u1edbn tr\u00ean, Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00e1c gi\u1ea3i ph\u00e1p to\u00e0n di\u1ec7n cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch trong h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1eeb vi\u1ec7c ph\u00e2n t\u00e1ch t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb m\u00e1u ngo\u1ea1i vi \u0111\u1ebfn t\u0103ng sinh v\u00e0 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o. Vi\u1ec7n \u0111\u00e3 ph\u00e1t tri\u1ec3n th\u00e0nh c\u00f4ng 4 quy tr\u00ecnh c\u00f4ng ngh\u1ec7 \u0111\u1ec3 c\u00f3 th\u1ec3 ph\u00e2n l\u1eadp v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch g\u1ed3m: quy tr\u00ecnh ph\u00e2n l\u1eadp t\u0103ng sinh t\u1ebf b\u00e0o NK, quy tr\u00ecnh ph\u00e2n l\u1eadp, c\u1ea3m \u1ee9ng v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o CIK, quy tr\u00ecnh ph\u00e2n l\u1eadp, t\u0103ng sinh v\u00e0 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o gamma delta T v\u00e0 quy tr\u00ecnh ph\u00e2n l\u1eadp, c\u1ea3m \u1ee9ng t\u1ebf b\u00e0o tua (dendritic cell).<\/p>\n\n\n\n<p>C\u00e1c quy tr\u00ecnh \u0111\u01b0\u1ee3c t\u1ed1i gi\u1ea3n c\u00e1c b\u01b0\u1edbc, d\u1ec5 t\u00e1i l\u1eadp, d\u1ec5 th\u1ef1c hi\u1ec7n, thu ho\u1ea1ch s\u1ea3n l\u01b0\u1ee3ng t\u1ebf b\u00e0o c\u1ef1c l\u1edbn (\u0111\u1ebfn h\u00e0ng t\u1ec9 t\u1ebf b\u00e0o), ho\u1ea1t l\u1ef1c t\u1ebf b\u00e0o m\u1ea1nh m\u1ebd. Quy tr\u00ecnh kh\u00f4ng s\u1eed d\u1ee5ng b\u1ea5t k\u00ec protein t\u1eeb \u0111\u1ed9ng v\u1eadt n\u00e0o cho n\u00ean \u0111\u00e1p \u1ee9ng t\u1ed1t c\u00e1c y\u00eau c\u1ea7u kh\u1eafc khe cho ch\u1ebf ph\u1ea9m sinh h\u1ecdc s\u1eed d\u1ee5ng tr\u00ean ng\u01b0\u1eddi.<\/p>\n\n\n\n<p><strong>Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c<\/strong> m\u1eddi g\u1ecdi c\u00e1c b\u1ea1n c\u00f3 quan t\u00e2m \u0111\u1ebfn c<strong>\u00f4ng ngh\u1ec7 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch ph\u1ee5c v\u1ee5 cho l\u00e2m s\u00e0ng <\/strong>\u0111\u1ebfn trao \u0111\u1ed5i tr\u1ef1c ti\u1ebfp v\u1edbi \u0111\u1ed9i ng\u0169 chuy\u00ean gia s\u1ea3n ph\u1ea9m c\u1ee7a ch\u00fang t\u00f4i t\u1ea1i<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Booth B163, Trung t\u00e2m Tri\u1ec3n l\u00e3m SECC, Qu\u1eadn 7, Tp.HCM t\u1eeb ng\u00e0y h\u00f4m nay (4\/8\/2023) \u0111\u1ebfn h\u1ebft ng\u00e0y mai (5\/8\/2023)<\/li>\n\n\n\n<li>Li\u00ean h\u1ec7 tr\u1ef1c ti\u1ebfp t\u1edbi Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM, khu ph\u1ed1 6, Linh Trung, Tp. Th\u1ee7 \u0110\u1ee9c, Tp. H\u1ed3 Ch\u00ed Minh qua email: <a href=\"mailto:contact@sci.edu.vn\">contact@sci.edu.vn<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00e1c gi\u1ea3i ph\u00e1p to\u00e0n di\u1ec7n cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch trong h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1eeb vi\u1ec7c ph\u00e2n t\u00e1ch t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb m\u00e1u ngo\u1ea1i vi \u0111\u1ebfn t\u0103ng sinh v\u00e0 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o. Vi\u1ec7n \u0111\u00e3 ph\u00e1t tri\u1ec3n th\u00e0nh c\u00f4ng 4 quy tr\u00ecnh c\u00f4ng ngh\u1ec7 \u0111\u1ec3 c\u00f3 th\u1ec3 ph\u00e2n l\u1eadp v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch g\u1ed3m: quy tr\u00ecnh ph\u00e2n l\u1eadp t\u0103ng sinh t\u1ebf b\u00e0o NK, quy tr\u00ecnh ph\u00e2n l\u1eadp, c\u1ea3m \u1ee9ng v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o CIK, quy tr\u00ecnh ph\u00e2n l\u1eadp, t\u0103ng sinh v\u00e0 ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o gamma delta T v\u00e0 quy tr\u00ecnh ph\u00e2n l\u1eadp, c\u1ea3m \u1ee9ng t\u1ebf b\u00e0o tua (dendritic cell).<\/p>\n","protected":false},"author":2,"featured_media":1026,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[31],"tags":[110,111,109,108],"class_list":["post-1024","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc","tag-cik","tag-gamma-delta-t","tag-nk","tag-tebaomiendich"],"jetpack_featured_media_url":"https:\/\/biomedmart.com.vn\/etc\/wp-content\/uploads\/2023\/08\/natural-killer-cell-isolated-white-background_521900-1125.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/1024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/comments?post=1024"}],"version-history":[{"count":1,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/1024\/revisions"}],"predecessor-version":[{"id":1027,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/1024\/revisions\/1027"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media\/1026"}],"wp:attachment":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media?parent=1024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/categories?post=1024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/tags?post=1024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}