{"id":187,"date":"2023-05-09T22:29:40","date_gmt":"2023-05-09T15:29:40","guid":{"rendered":"https:\/\/biomedmart.com.vn\/?p=187"},"modified":"2023-05-13T11:44:18","modified_gmt":"2023-05-13T04:44:18","slug":"tin-tuc-3","status":"publish","type":"post","link":"https:\/\/biomedmart.com.vn\/etc\/2023\/05\/09\/tin-tuc-3\/","title":{"rendered":"Exosome thu t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 m\u00f4 d\u00e2y r\u1ed1n k\u00edch th\u00edch t\u1ea1o m\u1ea1ch th\u00f4ng qua bi\u1ec3u hi\u1ec7n gen VWF v\u00e0 Flk1 \u1edf t\u1ebf b\u00e0o n\u1ed9i m\u00f4"},"content":{"rendered":"\n

Exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u01b0\u1ee3c xem l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 li\u00ean l\u1ea1c quan tr\u1ecdng \u0111\u1ec3 k\u00edch th\u00edch s\u1eeda ch\u1eefa m\u00f4 theo c\u01a1 ch\u1ebf paracrine, n\u00ean ch\u00fang \u0111\u00e3 \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t s\u1ea3n ph\u1ea9m \u0111i\u1ec1u tr\u1ecb m\u1edbi. C\u00e1c c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a exosome \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn bao g\u1ed3m gi\u1ea3m vi\u00eam, k\u00edch th\u00edch t\u0103ng sinh t\u1ebf b\u00e0o, \u1ee9c ch\u1ebf apoptosis, v\u00e0 k\u00edch th\u00edch h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u. Nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y c\u1ee7a Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM \u0111\u00e3 ti\u1ebfn h\u00e0nh nh\u1eb1m t\u00ecm hi\u1ec3u c\u01a1 ch\u1ebf c\u1ee7a exosome thu t\u1eeb m\u00f4 d\u00e2y r\u1ed1n ng\u01b0\u1eddi trong c\u01a1 ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u m\u1edbi. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

H\u00ecnh 1. So s\u00e1nh s\u1ef1 bi\u1ec3u hi\u1ec7n c\u00e1c gen sinh m\u1ea1ch gi\u1eefa t\u1ebf b\u00e0o HUVEC c\u00f3 v\u00e0 kh\u00f4ng c\u00f3 b\u1ed5 sung exosome trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i.<\/strong><\/p>\n\n\n\n

T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC) t\u1eeb m\u00f4 cu\u1ed1ng r\u1ed1n ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp b\u1eb1ng c\u00e1ch nu\u00f4i c\u1ea5y m\u00f4 trong m\u00f4i tr\u01b0\u1eddng MSCCult I primary v\u00e0 t\u0103ng sinh trong m\u00f4i tr\u01b0\u1eddng MSCCult I (Regenmedlab, VN). \u0110\u1ec3 thu nh\u1eadp exosome, MSC \u0111\u01b0\u1ee3c nu\u00f4i trong m\u00f4i tr\u01b0\u1eddng MSCCult MV (Regenmedlab) trong 48 gi\u1edd \u0111\u1ec3 thu exosome trong d\u1ecbch nu\u00f4i. Exosome \u0111\u01b0\u1ee3c thu ho\u1ea1ch t\u1eeb d\u1ecbch nu\u00f4i b\u1eb1ng k\u0129 thu\u1eadt si\u00eau li t\u00e2m. \u0110\u1ec3 t\u00ecm hi\u1ec3u c\u01a1 ch\u1ebf t\u0103ng sinh m\u1ea1ch, exosome \u0111\u01b0\u1ee3c b\u1ed5 sung v\u00e0o m\u00f4i tr\u01b0\u1eddng nu\u00f4i t\u1ebf b\u00e0o n\u1ed9i m\u00f4 (HUVEC). T\u00e1c \u0111\u1ed9ng c\u1ee7a exosome \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 qua \u0111\u00e1nh gi\u00e1 bi\u1ec3u hi\u1ec7n gen sinh m\u1ea1ch (MMP-2<\/em>, Ephrin B2<\/em>, Ephrin B4<\/em>, Flk1<\/em>, Flt1<\/em>, VWF<\/em>, VE-cadherin<\/em>, CD31<\/em>, ANG1<\/em>, ANG2<\/em>, v\u00e0 HGF<\/em>), v\u00e0 \u0111\u00e1nh gi\u00e1 h\u00ecnh th\u00e0nh c\u1ea5u tr\u00fac gi\u1ed1ng m\u1ea1ch m\u00e1u. <\/p>\n\n\n\n

K\u1ebft qu\u1ea3 cho th\u1ea5y r\u1eb1ng exosome thu t\u1eeb MSC cu\u1ed1ng r\u1ed1n k\u00edch th\u00edch bi\u1ec3u hi\u1ec7n m\u1ea1nh c\u00e1c gen HGF<\/em>, VWF<\/em>, CD31<\/em>, Flt1<\/em>,and Flk1<\/em> (\u0111\u1eb7c bi\u1ec7t 2 gen VWF<\/em> and Flt1<\/em>). T\u1eeb nh\u1eefng quan s\u00e1t n\u00e0y exosome t\u1eeb MSC c\u00f3 th\u1ec3 k\u00edch th\u00edch t\u0103ng sinh m\u1ea1ch th\u00f4ng qua k\u00edch th\u00edch bi\u1ec3u hi\u1ec7n 2 gen quan tr\u1ecdng cho s\u1ef1 t\u1ea1o m\u1ea1ch VWF<\/em> v\u00e0 Flt1<\/em> \u1edf t\u1ebf b\u00e0o n\u1ed9i m\u00f4. <\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 xu\u1ea5t b\u1ea3n t\u1ea1i \u0111\u00e2y: https:\/\/pubmed.ncbi.nlm.nih.gov\/37014542\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u01b0\u1ee3c xem l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 li\u00ean l\u1ea1c quan tr\u1ecdng \u0111\u1ec3 k\u00edch th\u00edch s\u1eeda ch\u1eefa m\u00f4 theo c\u01a1 ch\u1ebf paracrine, n\u00ean ch\u00fang \u0111\u00e3 \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t s\u1ea3n ph\u1ea9m \u0111i\u1ec1u tr\u1ecb m\u1edbi. C\u00e1c c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a exosome \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn bao g\u1ed3m gi\u1ea3m vi\u00eam, k\u00edch […]<\/p>\n","protected":false},"author":2,"featured_media":317,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[31],"tags":[],"class_list":["post-187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"jetpack_featured_media_url":"https:\/\/biomedmart.com.vn\/etc\/wp-content\/uploads\/2023\/05\/Figure-2xxx.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/comments?post=187"}],"version-history":[{"count":4,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/187\/revisions"}],"predecessor-version":[{"id":319,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/187\/revisions\/319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media\/317"}],"wp:attachment":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media?parent=187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/categories?post=187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/tags?post=187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}