{"id":2100,"date":"2025-07-26T00:00:47","date_gmt":"2025-07-25T17:00:47","guid":{"rendered":"https:\/\/biomedmart.com.vn\/?p=2100"},"modified":"2025-07-26T00:00:47","modified_gmt":"2025-07-25T17:00:47","slug":"exosome-tu-te-bao-goc-mo-mo-cai-thien-tinh-trang-lao-hoa-da","status":"publish","type":"post","link":"https:\/\/biomedmart.com.vn\/etc\/2025\/07\/26\/exosome-tu-te-bao-goc-mo-mo-cai-thien-tinh-trang-lao-hoa-da\/","title":{"rendered":"Exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da"},"content":{"rendered":"\n
\"\"<\/a><\/figure>\n\n\n\n

\"\u23f3\"L\u00e3o h\u00f3a da, b\u1ecb chi ph\u1ed1i b\u1edfi nhi\u1ec1u y\u1ebfu t\u1ed1 n\u1ed9i sinh v\u00e0 ngo\u1ea1i sinh , \u0111\u1eb7c bi\u1ec7t l\u00e0 vi\u1ec7c ti\u1ebfp x\u00fac k\u00e9o d\u00e0i v\u1edbi tia UV , g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 th\u1ea9m m\u1ef9 v\u00e0 y khoa nh\u01b0 n\u1ebfp nh\u0103n s\u00e2u, kh\u00f4 da, v\u00e0 r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed1. C\u00e1c li\u1ec7u ph\u00e1p truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 k\u00edch \u1ee9ng, m\u1ea9n \u0111\u1ecf. Trong b\u1ed1i c\u1ea3nh \u0111\u00f3, m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111\u1ea7y h\u1ee9a h\u1eb9n l\u00e0 \u1ee9ng d\u1ee5ng tr\u1ecb li\u1ec7u exosome c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb <\/a>t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 (ADSCs).<\/p>\n\n\n\n

\"\ud83d\udc68\u200d\ud83d\udd2c\"\"\ud83d\udc69\u200d\ud83d\udd2c\"Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u00e2y c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1eeb Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean, \u0110HQG Tp.HCM v\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y d\u01b0\u1ee3c Tp.HCM \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u00f3 t\u00e1c d\u1ee5ng c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean t\u1ea1p ch\u00ed uy t\u00edn Clinical, Cosmetic and Investigational Dermatology.<\/p>\n\n\n\n

Exosome l\u00e0 c\u00e1c t\u00fai ngo\u1ea1i b\u00e0o k\u00edch th\u01b0\u1edbc nano, tham gia truy\u1ec1n th\u00f4ng tin gi\u1eefa c\u00e1c t\u1ebf b\u00e0o. Kh\u00e1c v\u1edbi li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o, exosome l\u00e0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c “kh\u00f4ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o”, gi\u00fap gi\u1ea3m r\u00e0o c\u1ea3n s\u1eed d\u1ee5ng v\u00e0 c\u1ea3i thi\u1ec7n t\u00ednh an to\u00e0n.<\/p>\n\n\n\n

\"\ud83d\udcd8\"Ph\u01b0\u01a1ng ph\u00e1p nghi\u00ean c\u1ee9u:<\/p>\n\n\n\n

– T\u1ea1o exosome trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy (hypADSC-Exo): Nghi\u00ean c\u1ee9u \u0111\u00e3 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy (d\u01b0\u1edbi 5% O2), gi\u00fap ch\u00fang s\u1ed1ng s\u00f3t v\u00e0 t\u0103ng sinh t\u1ed1t h\u01a1n, \u0111\u1ed3ng th\u1eddi t\u1ea1o ra exosome v\u1edbi th\u00e0nh ph\u1ea7n ph\u00e2n t\u1eed \u0111\u1eb7c bi\u1ec7t, ch\u1ee9a microRNA v\u00e0 protein b\u1ea3o v\u1ec7 gi\u00fap ch\u1ed1ng l\u1ea1i stress oxy h\u00f3a v\u00e0 th\u00fac \u0111\u1ea9y t\u00e1i t\u1ea1o da hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n\n\n\n

– Th\u1eed nghi\u1ec7m tr\u00ean t\u1ebf b\u00e0o (in vitro): Nh\u00f3m t\u00e1c gi\u1ea3 \u0111\u00e3 s\u1eed d\u1ee5ng nguy\u00ean b\u00e0o s\u1ee3i da ng\u01b0\u1eddi (HDFs) b\u1ecb l\u00e3o h\u00f3a do b\u1ee9c x\u1ea1 UV \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng c\u1ee7a hypADSC-Exo. C\u00e1c nguy\u00ean b\u00e0o s\u1ee3i l\u00e3o h\u00f3a \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1eb1ng hypADSC-Exo \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 thay \u0111\u1ed5i v\u1ec1 h\u00ecnh th\u00e1i, t\u1ed1c \u0111\u1ed9 t\u0103ng sinh, c\u0169ng nh\u01b0 bi\u1ec3u hi\u1ec7n gene li\u00ean quan l\u00e3o h\u00f3a.<\/p>\n\n\n\n

– Th\u1eed nghi\u1ec7m tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt (in vivo): Nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng m\u00f4 h\u00ecnh chu\u1ed9t b\u1ecb l\u00e3o h\u00f3a da do ti\u1ebfp x\u00fac UV m\u00e3n t\u00ednh. HypADSC-Exo \u0111\u01b0\u1ee3c b\u00f4i t\u1ea1i ch\u1ed7 2 l\u1ea7n m\u1ed7i tu\u1ea7n trong 6 tu\u1ea7n, k\u00e8m theo \u0111\u00e1nh gi\u00e1 \u0111\u1ecbnh k\u1ef3 v\u1ec1 h\u1ec7 s\u1ed1 nh\u0103n, \u0111\u1ed9 d\u00e0y da, \u0111\u1ed9 \u1ea9m v\u00e0 \u0111\u1ed9 \u0111\u00e0n h\u1ed3i.<\/p>\n\n\n\n

K\u1ebft qu\u1ea3 n\u1ed5i b\u1eadt:<\/p>\n\n\n\n

– Hi\u1ec7u qu\u1ea3 ch\u1ed1ng l\u00e3o h\u00f3a r\u00f5 r\u1ec7t: X\u1eed l\u00fd nguy\u00ean b\u00e0o s\u1ee3i HDFs b\u1ecb t\u1ed5n th\u01b0\u01a1ng b\u1edfi UV v\u1edbi hypADSC-Exo gi\u00fap gi\u1ea3m c\u00e1c d\u1ea5u hi\u1ec7u l\u00e3o h\u00f3a h\u00ecnh th\u00e1i v\u00e0 kh\u00f4i ph\u1ee5c k\u00edch th\u01b0\u1edbc t\u1ebf b\u00e0o g\u1ea7n b\u00ecnh th\u01b0\u1eddng, duy tr\u00ec kh\u1ea3 n\u0103ng t\u0103ng sinh v\u00e0 gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u00e1c marker l\u00e3o h\u00f3a (p16, p21).<\/p>\n\n\n\n

– C\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng da: Tr\u00ean m\u00f4 h\u00ecnh chu\u1ed9t, hypADSC-Exo \u1edf li\u1ec1u cao h\u01a1n gi\u00fap gi\u1ea3m n\u1ebfp nh\u0103n, t\u0103ng \u0111\u1ed9 \u1ea9m v\u00e0 \u0111\u1ed9 \u0111\u00e0n h\u1ed3i c\u1ee7a da, v\u1edbi r\u1ea5t \u00edt d\u1ea5u hi\u1ec7u k\u00edch \u1ee9ng.<\/p>\n\n\n\n

– T\u00e1i t\u1ea1o collagen: \u0110\u00e1nh gi\u00e1 m\u00f4 h\u1ecdc cho th\u1ea5y l\u1edbp bi\u1ec3u b\u00ec chu\u1ed9t \u0111\u01b0\u1ee3c b\u00f4i hypADSC-Exo gi\u1ea3m hi\u1ec7n t\u01b0\u1ee3ng t\u0103ng s\u1ea3n, \u0111\u1ed3ng th\u1eddi m\u1eadt \u0111\u1ed9 collagen cao h\u01a1n. S\u1ef1 c\u1ea3i thi\u1ec7n n\u00e0y \u0111\u1ebfn t\u1eeb vi\u1ec7c h\u1ea1 th\u1ea5p ho\u1ea1t \u0111\u1ed9ng c\u1ee7a metalloproteinase (MMP) v\u00e0 t\u0103ng bi\u1ec3u hi\u1ec7n gene collagen lo\u1ea1i I v\u00e0 III.<\/p>\n\n\n\n

\"\ud83d\udcd8\"\u00dd ngh\u0129a v\u00e0 khuy\u1ebfn ngh\u1ecb:<\/p>\n\n\n\n

– Nghi\u00ean c\u1ee9u n\u00e0y c\u1ee7ng c\u1ed1 ti\u1ec1m n\u0103ng c\u1ee7a exosome nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p “kh\u00f4ng t\u1ebf b\u00e0o” thay th\u1ebf cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c truy\u1ec1n th\u1ed1ng. \u0110\u1ed3ng th\u1eddi, n\u00f3 nh\u1ea5n m\u1ea1nh \u01b0u th\u1ebf c\u1ee7a exosome t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u1ee1 \u0111\u01b0\u1ee3c nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy, m\u1edf ra h\u01b0\u1edbng ph\u00e1t tri\u1ec3n c\u00e1c s\u1ea3n ph\u1ea9m d\u01b0\u1ee3c m\u1ef9 ph\u1ea9m m\u1edbi, d\u1ec5 ti\u00eau chu\u1ea9n h\u00f3a v\u00e0 s\u1eed d\u1ee5ng h\u01a1n.<\/p>\n\n\n\n

– D\u00f9 c\u1ea7n th\u00eam kh\u1ea3o s\u00e1t v\u1ec1 li\u1ec1u d\u00f9ng t\u1ed1i \u01b0u v\u00e0 t\u00e1c \u0111\u1ed9ng d\u00e0i h\u1ea1n , c\u00f4ng tr\u00ecnh n\u00e0y \u0111\u00e3 \u0111\u1eb7t n\u1ec1n m\u00f3ng cho nh\u1eefng \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng \u0111\u1ea7y h\u1ee9a h\u1eb9n , g\u00f3p ph\u1ea7n “c\u00e1ch m\u1ea1ng h\u00f3a” cu\u1ed9c chi\u1ebfn d\u00e0i h\u01a1i ch\u1ed1ng l\u1ea1i l\u00e3o h\u00f3a da do \u00e1nh s\u00e1ng.<\/p>\n\n\n\n

\u0110\u1ecdc to\u00e0n v\u0103n nghi\u00ean c\u1ee9u t\u1ea1i: https:\/\/doi.org\/10.2147\/CCID.S523936<\/a><\/p>\n\n\n\n

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L\u00e3o h\u00f3a da, b\u1ecb chi ph\u1ed1i b\u1edfi nhi\u1ec1u y\u1ebfu t\u1ed1 n\u1ed9i sinh v\u00e0 ngo\u1ea1i sinh , \u0111\u1eb7c bi\u1ec7t l\u00e0 vi\u1ec7c ti\u1ebfp x\u00fac k\u00e9o d\u00e0i v\u1edbi tia UV , g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 th\u1ea9m m\u1ef9 v\u00e0 y khoa nh\u01b0 n\u1ebfp nh\u0103n s\u00e2u, kh\u00f4 da, v\u00e0 r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed1. C\u00e1c li\u1ec7u ph\u00e1p truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng […]<\/p>\n","protected":false},"author":27,"featured_media":2101,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[31],"tags":[141,58,56,104,135,106,123,105],"class_list":["post-2100","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc","tag-dalieu","tag-huyettuonggiautieucau","tag-prp","tag-regenerativemedicine","tag-sci","tag-tebaogoc","tag-vientebaogoc","tag-yhoctaitao"],"jetpack_featured_media_url":"https:\/\/biomedmart.com.vn\/etc\/wp-content\/uploads\/2025\/07\/E295D342-0D68-4211-BB6B-C8E7D071D3EF.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/comments?post=2100"}],"version-history":[{"count":1,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2100\/revisions"}],"predecessor-version":[{"id":2103,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2100\/revisions\/2103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media\/2101"}],"wp:attachment":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media?parent=2100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/categories?post=2100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/tags?post=2100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}