{"id":2109,"date":"2025-08-30T14:52:44","date_gmt":"2025-08-30T07:52:44","guid":{"rendered":"https:\/\/biomedmart.com.vn\/?p=2109"},"modified":"2025-08-30T14:52:44","modified_gmt":"2025-08-30T07:52:44","slug":"dich-nuoi-cay-tu-te-bao-goc-trung-mo-nhau-thai-va-mang-dem-o-nguoi-uc-che-su-di-chuyen-va-xam-lan-cua-te-bao-ung-thu-duong-mat-bang-cach-uc-che-con-duong-pi3k-akt","status":"publish","type":"post","link":"https:\/\/biomedmart.com.vn\/etc\/2025\/08\/30\/dich-nuoi-cay-tu-te-bao-goc-trung-mo-nhau-thai-va-mang-dem-o-nguoi-uc-che-su-di-chuyen-va-xam-lan-cua-te-bao-ung-thu-duong-mat-bang-cach-uc-che-con-duong-pi3k-akt\/","title":{"rendered":"D\u1ecbch nu\u00f4i c\u1ea5y t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 nhau thai v\u00e0 m\u00e0ng \u0111\u1ec7m \u1edf ng\u01b0\u1eddi \u1ee9c ch\u1ebf s\u1ef1 di chuy\u1ec3n v\u00e0 x\u00e2m l\u1ea5n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 \u0111\u01b0\u1eddng m\u1eadt b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng PI3K\/AKT"},"content":{"rendered":"\n<p>Ung th\u01b0 \u0111\u01b0\u1eddng m\u1eadt (cholangiocarcinoma \u2013 CCA) l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i ung th\u01b0 \u00e1c t\u00ednh nguy hi\u1ec3m nh\u1ea5t. C\u0103n b\u1ec7nh n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n mu\u1ed9n, d\u1ec5 di c\u0103n v\u00e0 kh\u00e1ng l\u1ea1i nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb, khi\u1ebfn t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t r\u1ea5t th\u1ea5p. Hi\u1ec7n nay, ph\u1eabu thu\u1eadt l\u00e0 l\u1ef1a ch\u1ecdn kh\u1ea3 d\u0129 nh\u1ea5t, nh\u01b0ng ch\u1ec9 \u00e1p d\u1ee5ng \u0111\u01b0\u1ee3c cho s\u1ed1 \u00edt b\u1ec7nh nh\u00e2n; ph\u1ea7n l\u1edbn c\u00f2n l\u1ea1i bu\u1ed9c ph\u1ea3i d\u1ef1a v\u00e0o h\u00f3a tr\u1ecb v\u1ed1n \u00edt hi\u1ec7u qu\u1ea3.<\/p>\n\n\n\n<p>M\u1ed9t nghi\u00ean c\u1ee9u c\u00f4ng b\u1ed1 tr\u00ean <em>Scientific Reports<\/em> (2025) mang \u0111\u1ebfn h\u01b0\u1edbng \u0111i tri\u1ec3n v\u1ecdng: s\u1eed d\u1ee5ng d\u1ecbch d\u1ecbch nu\u00f4i c\u1ea5y (conditioned media \u2013 CM) t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 l\u1ea5y t\u1eeb m\u00e0ng \u0111\u1ec7m (CH-MSCs) v\u00e0 nhau thai (PL-MSCs). Thay v\u00ec c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1eadn d\u1ee5ng d\u1ecbch nu\u00f4i c\u1ea5y ch\u1ee9a c\u00e1c y\u1ebfu t\u1ed1 h\u00f2a tan do MSCs ti\u1ebft ra \u2013 an to\u00e0n h\u01a1n v\u00e0 d\u1ec5 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p>\u1ede n\u1ed3ng \u0111\u1ed9 75%, d\u1ecbch nu\u00f4i c\u1ea5y CH-CM v\u00e0 PL-CM \u0111\u00e3 l\u00e0m gi\u1ea3m t\u1edbi <strong>80% s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o ung th\u01b0<\/strong> ch\u1ec9 sau 72 gi\u1edd. Trong th\u1eed nghi\u1ec7m di chuy\u1ec3n, t\u1ed1c \u0111\u1ed9 c\u1ee7a d\u00f2ng KKU213A gi\u1ea3m t\u1eeb <strong>77,83% xu\u1ed1ng 12,25% (CH-CM)<\/strong> v\u00e0 <strong>1,98% (PL-CM)<\/strong>. Trong khi \u0111\u00f3, kh\u1ea3 n\u0103ng x\u00e2m l\u1ea5n b\u1ecb ch\u1eb7n \u0111\u1ee9ng, gi\u1ea3m h\u01a1n <strong>95%<\/strong>, ch\u1ec9 c\u00f2n 2\u20133% so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng.<\/p>\n\n\n\n<p>Ph\u00e2n t\u00edch ph\u00e2n t\u1eed cho th\u1ea5y c\u00e1c y\u1ebfu t\u1ed1 t\u1eeb MSCs \u0111\u00e3 <strong>\u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u PI3K\/AKT<\/strong> \u2013 m\u1ed9t \u201cc\u00f4ng t\u1eafc\u201d quan tr\u1ecdng th\u00fac \u0111\u1ea9y t\u0103ng sinh v\u00e0 di c\u0103n ung th\u01b0. \u0110\u1ed3ng th\u1eddi, ch\u00fang c\u00f2n ch\u1eb7n qu\u00e1 tr\u00ecnh <strong>chuy\u1ec3n d\u1ea1ng bi\u1ec3u m\u00f4 \u2013 trung m\u00f4 (EMT)<\/strong>, khi\u1ebfn t\u1ebf b\u00e0o ung th\u01b0 m\u1ea5t kh\u1ea3 n\u0103ng \u201ctho\u00e1t ra v\u00e0 lan r\u1ed9ng\u201d.<\/p>\n\n\n\n<p>\u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a d\u1ecbch ti\u1ebft MSCs t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, th\u1eadm ch\u00ed v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf PI3K chuy\u00ean bi\u1ec7t, nh\u01b0ng an to\u00e0n h\u01a1n v\u00ec kh\u00f4ng \u0111\u01b0a t\u1ebf b\u00e0o s\u1ed1ng v\u00e0o c\u01a1 th\u1ec3. \u0110\u00e2y \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c \u0111\u1ea7y h\u1ee9a h\u1eb9n, c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p hi\u1ec7n t\u1ea1i \u0111\u1ec3 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 k\u00e9o d\u00e0i s\u1ef1 s\u1ed1ng cho b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u01b0\u1eddng m\u1eadt.<\/p>\n\n\n\n<p>\u0110\u1ecdc to\u00e0n v\u0103n: <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-16789-6\">https:\/\/www.nature.com\/articles\/s41598-025-16789-6<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ung th\u01b0 \u0111\u01b0\u1eddng m\u1eadt (cholangiocarcinoma \u2013 CCA) l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i ung th\u01b0 \u00e1c t\u00ednh nguy hi\u1ec3m nh\u1ea5t. C\u0103n b\u1ec7nh n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n mu\u1ed9n, d\u1ec5 di c\u0103n v\u00e0 kh\u00e1ng l\u1ea1i nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb, khi\u1ebfn t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t r\u1ea5t th\u1ea5p. Hi\u1ec7n nay, ph\u1eabu thu\u1eadt l\u00e0 l\u1ef1a ch\u1ecdn kh\u1ea3 d\u0129 nh\u1ea5t, [&hellip;]<\/p>\n","protected":false},"author":27,"featured_media":2110,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[31],"tags":[104,112,135,106,123,105],"class_list":["post-2109","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc","tag-regenerativemedicine","tag-regenmedlab","tag-sci","tag-tebaogoc","tag-vientebaogoc","tag-yhoctaitao"],"jetpack_featured_media_url":"https:\/\/biomedmart.com.vn\/etc\/wp-content\/uploads\/2025\/08\/1.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/comments?post=2109"}],"version-history":[{"count":1,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2109\/revisions"}],"predecessor-version":[{"id":2111,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/posts\/2109\/revisions\/2111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media\/2110"}],"wp:attachment":[{"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/media?parent=2109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/categories?post=2109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedmart.com.vn\/etc\/wp-json\/wp\/v2\/tags?post=2109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}